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How THC & CBD Work (2 of 2)

Updated: Mar 17, 2020

The Endocannabinoid System


Cannabis works on more than just CB1 & CB2


Three more receptors that cannabis hits - TRPV1, PPARgamma & PPARalpha


If you haven't read up on part 1 of this two part series. You can find it here (click me).

TRPV1 (a capsaicin receptor)

  • Location: neuronal somata in hippocampus & cerebellum

Actions:

  • Work on gabanergic (relax) & glutamatergic (excite) terminals

  • Regulation of mood, fear, memory, food intake, visual development & locomotion

  • Mediates long-term depression through upregulation of AMPA receptor reuptake


PPARgamma, PPARalpha (receptors that help regulate gene expression)

  • Location: expressed in neurons, astrocytes, microglia

Actions:

  • Anti-inflammatory & neuroprotective effects during acute & chronic neuroinflammatory insults (i.e. trauma, ischemia, AD, MS)

  • PPARalpha - may reduce dependence of nicotine & appetite

  • Both compounds: impact alcohol dependence


Author: David Katz | DavidKatz@cox.net


Reference:

Cristino L, Bisogno T, Di Marzo V. Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nat Rev Neurol. 2020;16(1):9-29. doi:10.1038/s41582-019-0284-z

Link to reference (click here)


Figure 1: The expanded endocannabinoid system

Figure 2: Neurophysiological roles of the expanded endocannabinoid system

Figure 3: Endocannabinoidome receptors in acute or degenerative neurological disorders



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